Jian Zhang

Lifespan Trajectories of Resting State Bipolar EEG Power

The paper derives lifespan trajectories of resting state bipolar EEG power from a large sample, finding age-related decreases followed by divergent patterns and sex-specific inter-frequency correlations.

The HES1-SOD1 Antagonism Shapes Senescence Heterogeneity and Impacts Metastatic Relapse of Circulating Tumor Cells

This study identifies two HES1-expressing senescent CTC subpopulations with distinct metabolic and clinical outcomes, showing HES1-SOD1 antagonism influences metastatic relapse.

Targeting folate-dependent purine synthesis sensitizes melanoma cells to immune attack through suppressing glycolysis

This study shows that inhibiting folate-dependent purine synthesis in melanoma cells enhances their sensitivity to T cell killing by suppressing glycolysis and reducing PD-L1 stability.

Lifespan Trajectories of Resting State EEG power

The paper analyzes resting state EEG power trajectories across age and sex in a large sample, finding age-related decreases and sex-specific reversals in certain frequency bands.

Inhibiting RhoA Activation via GDP-state Stabilization to Relieve Heart Failure

This study identifies a compound that inhibits RhoA activation by stabilizing its GDP state, reducing myocardial remodeling and fibrosis in heart failure models.

MAP: A Knowledge-driven Framework for Predicting Single-cell Responses for Unprofiled Drugs

MAP predicts single-cell responses to unprofiled drugs using a knowledge-driven framework that integrates biological knowledge and improves performance over baselines.

Sampling Function-Related Metastable States of Proteins With DASH

DASH samples function-related metastable states of proteins, revealing new folding states and allosteric sites, verified by experiments and crystal structures.

Overcoming rapaprotin resistance through inhibition of P-glycoprotein

This study identifies P-glycoprotein as a mediator of Rapaprotin resistance and shows that co-treatment with tariquidar restores its efficacy in colorectal cancer cells.

Effect and Mechanism Analysis of Melittin on Promoting Muscle Differentiation of Adipose Stem Cells

This study shows melittin promotes adipose stem cell (ADSC) muscle differentiation and improves skeletal muscle atrophy in rats via the p38-MAPK pathway.

Ythdf2 ablation protects aged retina from RGC dendrite shrinking and visual decline

This study shows that removing Ythdf2 in aged mice prevents RGC dendrite shrinkage and vision loss by targeting Hspa12a and Islr2.

Chinese fir genome and the evolution of gymnosperms

The paper presents the genome of Chinese fir, revealing evolutionary insights into gymnosperms and seed plant origins through phylogenomic and genomic analyses.

The m6A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells

This study shows YTHDF2 negatively regulates RGC dendrite development and maintenance, with its knockout improving visual acuity and protecting against glaucoma in mice.