Author

Istvan Botos

National Institutes of HealthORCID 0000-0002-7702-6749Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:E. coli· 2 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

Rodolfo GhirlandoiD· 3 shared Susan K. BuchananiD· 3 shared Bridgette M. BeachiD· 2 shared Amila H. Abeykoon· 1 shared Angela C. O’DonnelliD· 1 shared Ann Marie StanleyiD· 1 shared Anushya PetchiappaniD· 1 shared Bryan W. DaviesiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersMolecular Biology

Rodolfo GhirlandoORCID

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3 papers

Recent·Most cited

Structural and functional insights into the Rcs phosphorelay

Melesse Nune, Anushya Petchiappan, Istvan Botos, Nadim Majdalani, Sydney H. Shapiro, Rodolfo Ghirlando, Chin‐Hsien Tai, Amila H. Abeykoon, Ann Marie Stanley, Bridgette M. Beach, Susan Gottesman, Susan K. Buchanan

This study determines the structures of Rcs phosphorelay components and describes how RcsF activates the system by modifying IgaA/RcsD interactions.

bioRxiv · May 9, 2026 · PreprintBiophysics

Structural Insights into Cir-mediated Killing by the Antimicrobial Protein Microcin V

Stavros A. Maurakis, Angela C. O’Donnell, Istvan Botos, Rodolfo Ghirlando, Bryan W. Davies, Susan K. Buchanan

The paper reports the first high-resolution structure of the Cir/MccV complex and identifies key residues critical for MccV binding and bacteriolysis.

Communications Biology · Oct 9, 2025Peer-reviewedMolecular Biology

Cryo-EM structures of the E. coli Ton and Tol motor complexes

Hervé Celia, Istvan Botos, Rodolfo Ghirlando, Denis Duché, Bridgette M. Beach, Roland Lloubès, Susan K. Buchanan

This paper presents high-resolution Cryo-EM structures of the E. coli TonB-ExbB-ExbD and TolA-TolQ-TolR complexes, revealing their architecture and interaction mechanisms.

Nature Communications · Jul 1, 2025Peer-reviewedMolecular Biology