Rodolfo Ghirlando

This study shows APOE genotypes alter astrocytic lipid droplet proteomes and dynamics, with APOE4 showing resistance to lipophagy, suggesting impaired clearance as a mechanism for AD risk.

This study determines the structures of Rcs phosphorelay components and describes how RcsF activates the system by modifying IgaA/RcsD interactions.

This study investigates the structural basis of TDP-43 C-terminal domain multimerization using biophysical experiments, AlphaFold2-Multimer, and simulations, revealing helical oligomerization and the role of specific residues in phase separation and disease.

The paper reports the first high-resolution structure of the Cir/MccV complex and identifies key residues critical for MccV binding and bacteriolysis.

This paper presents high-resolution Cryo-EM structures of the E. coli TonB-ExbB-ExbD and TolA-TolQ-TolR complexes, revealing their architecture and interaction mechanisms.

This study defines the epitope, specificity, and mechanism of the J2 monoclonal antibody, revealing its unique recognition of dsRNA and implications for RNA research.

This study investigates how N-terminal phosphorylation and asymmetric transposon ends regulate piggyBac transposition in mammalian cells, revealing mechanisms that inhibit the process.