Author

Melesse Nune

National Institutes of HealthORCID 0000-0002-3385-3320Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1 Organism:yeast· 1

Frequent Co-Authors

Amila H. Abeykoon· 1 shared Ann Marie StanleyiD· 1 shared Anushya PetchiappaniD· 1 shared Bridgette M. BeachiD· 1 shared Chin‐Hsien TaiiD· 1 shared Cynthia WolbergeriD· 1 shared Istvan BotosiD· 1 shared Jonas ZaehringeriD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiophysics

Amila H. Abeykoon

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2 papers

Recent·Most cited

FACT frees Ubp10 from nucleosome sequestration after rapid H2B deubiquitination

Raquel Merino-Urteaga, Jonas Zaehringer, Melesse Nune, Cynthia Wolberger, Taekjip Ha

The paper shows that FACT facilitates Ubp10 release from nucleosomes after H2B deubiquitination, revealing release as the rate-limiting step for Ubp10 turnover.

bioRxiv · Nov 9, 2026 · PreprintBiophysics

Structural and functional insights into the Rcs phosphorelay

Melesse Nune, Anushya Petchiappan, Istvan Botos, Nadim Majdalani, Sydney H. Shapiro, Rodolfo Ghirlando, Chin‐Hsien Tai, Amila H. Abeykoon, Ann Marie Stanley, Bridgette M. Beach, Susan Gottesman, Susan K. Buchanan

This study determines the structures of Rcs phosphorelay components and describes how RcsF activates the system by modifying IgaA/RcsD interactions.

bioRxiv · May 9, 2026 · PreprintBiophysics