Rap1 Activates Endosomal AC9 to Drive the Second cAMP Wave
Xiangyu Zhang, Alejandro Pizzoni, Alípio Pinto, Daniel L. Altschuler
The paper identifies Rap1b as a direct activator of endosomal AC9, revealing a new mechanism for the endosomal cAMP wave in GsPCR signaling.
bioRxiv · May 11, 2026 · PreprintCell Biology