Caio César de Melo Freire

This study identifies four recurrent dengue envelope protein interaction architectures using computational methods and suggests viral stability depends on local network context.

This paper uses pressure and temperature to study how TMV coat protein assembly changes, revealing localized structural dynamics and epitope masking under high pressure.

The paper identifies broad-spectrum antiviral scaffolds against multiple flaviviruses using integrative proteome-wide virtual screening and docking.

The paper presents an open-source workflow for multi-target compound prioritization in drug discovery, integrating docking, ADME descriptors, and chemoinformatics for flaviviruses.

The paper uses molecular dynamics to show that antiviral compounds active against Dengue virus bind to similar sites on Zika virus proteins NS5, NS3, and Envelope.

The paper shows that the recent spread of the Asian Zika virus lineage is linked to NS1 codon usage adaptation to human genes, enhancing viral replication and fitness.