Author

Xinrui L. Zhang

Case Western Reserve UniversityORCID 0000-0002-7728-6970Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Evan S. DenerisiD· 2 shared Nobuko TabuchiiD· 2 shared William C. SpenceriD· 2 shared Brent EastmaniD· 1 shared Meagan M. KittiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 9 mutual co-author links

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2 shared papersNeuroscience

Evan S. DenerisORCID

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2 papers

Recent·Most cited

LMX1B missense-perturbation of regulatory element footprints disrupts serotonergic forebrain axon arborization

Brent Eastman, Nobuko Tabuchi, Xinrui L. Zhang, William C. Spencer, Evan S. Deneris

This study models human LMX1B missense mutations in mice, showing they disrupt serotonin axon arbor formation and regulatory element binding, affecting brain development and function.

Proceedings of the National Academy of Sciences · Apr 1, 2025Peer-reviewedNeuroscience

Reorganization of postmitotic neuronal chromatin accessibility for maturation of serotonergic identity

Xinrui L. Zhang, W. Clay Spencer, Nobuko Tabuchi, Meagan M. Kitt, Evan S. Deneris

The paper shows that Pet1 and Lmx1b regulate chromatin accessibility in postmitotic neurons to drive serotonergic identity maturation.

eLife · Apr 26, 2022Peer-reviewedNeuroscience