Author

W. Clay Spencer

Case Western Reserve UniversityORCID 0000-0002-9700-8011Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Evan S. DenerisiD· 2 shared Nobuko TabuchiiD· 2 shared Xinrui L. ZhangiD· 2 shared Brent EastmaniD· 1 shared Meagan M. KittiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 9 mutual co-author links

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2 shared papersNeuroscience

Evan S. DenerisORCID

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2 papers

Recent·Most cited

NeuroscienceProceedings of the National Academy of SciencesPeer-reviewedApr 1, 2025

LMX1B missense-perturbation of regulatory element footprints disrupts serotonergic forebrain axon arborization

Brent Eastman, Nobuko Tabuchi, Xinrui L. Zhang…·Evan S. Deneris

This study models human LMX1B missense mutations in mice, showing they disrupt serotonin axon arbor formation and regulatory element binding, affecting brain development and function.

2 citations

mouseDNA methylation

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NeuroscienceeLifePeer-reviewedApr 26, 2022

Reorganization of postmitotic neuronal chromatin accessibility for maturation of serotonergic identity

Xinrui L. Zhang, W. Clay Spencer, Nobuko Tabuchi…·Evan S. Deneris

The paper shows that Pet1 and Lmx1b regulate chromatin accessibility in postmitotic neurons to drive serotonergic identity maturation.

14 citations

mouseATAC-seq

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