Identification of the orphan GPR25 as a receptor of the chemokine CXCL17
Wenfeng Hu, Jie Yu, Juanjuan Wang, Ru‐Jiao Sun, Yong‐Shan Zheng, Teng Zhang, Y.-L. Liu, Zeng‐Guang Xu, Zhan‐Yun Guo
This study identifies GPR25 as the receptor for CXCL17 using AlphaFold 3 prediction and NanoBiT-based assays, showing specific activation and structural binding.
FEBS Journal · Apr 25, 2025Peer-reviewedBiochemistry