Zhan‐Yun Guo

This study engineers potent avian GPR25 agonists by grafting a fragment from an ostrich CXCL17 gene relic onto other species' CXCL17 proteins, showing enhanced activity at avian GPR25 receptors.

This study identifies functional CXCL17 orthologs in reptiles and shows their loss in birds, using bioinformatics and recombinant protein assays.

This study identifies and functionally characterizes GPR15LG orthologs in fish, showing their conserved signaling with GPR15 and evolutionary origin in ancient fish ancestors.

This study identifies a functional CXCL17-GPR25 system in the coelacanth, supporting its evolutionary origin in ancient fishes and transmission to vertebrates.

This study identifies and functionally characterizes CXCL17 orthologs in amphibians, revealing conserved mechanisms of GPR25 receptor activation.

This study identifies and functionally characterizes CXCL17 in cartilaginous fishes, revealing its ancient origin in the CXCL17-GPR25 signaling pathway.

This study identifies and functionally characterizes two CXCL17 paralogs in zebrafish, showing they bind and activate GPR25 and induce chemotaxis.

This study confirms that CXCL17 activates MRGPRX2, MRGPRX1, and MAS1 independently of its C-terminal fragment, unlike its effect on GPR25.

This study shows human CXCL17 activates and binds to fish GPR25 orthologs, suggesting conservation of the CXCL17-GPR25 interaction across vertebrates.

This study identifies GPR25 as the receptor for CXCL17 using AlphaFold 3 prediction and NanoBiT-based assays, showing specific activation and structural binding.

The paper tests if MYDGF is a ligand for S1PR2 using functional assays and finds it is not.