Author

Dario De Vecchis

Ruhr University BochumORCID 0000-0002-7732-5095Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Approach:experimental assay· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Approach:statistical model· 1

Frequent Co-Authors

Lars V. SchäferiD· 2 shared Markus A. SeegeriD· 2 shared Andrey Yu. GruzinoviD· 1 shared Cedric A J Hutter· 1 shared Clement Emmanuel BlanchetiD· 1 shared Henning TidowiD· 1 shared Imre GondaiD· 1 shared Inokentijs JostsiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Lars V. SchäferORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Capturing transient states of heterodimeric ABC transporter TM287/288 by Time-Resolved Small-Angle X-ray Scattering

Lea Schröder, Dario De Vecchis, Andrey Yu. Gruzinov, Lars V. Schäfer, Clement Emmanuel Blanchet, Markus A. Seeger, Henning Tidow, Inokentijs Josts

This study captures transient states of the ABC transporter TM287/288 using time-resolved small-angle X-ray scattering and reveals a transient occluded state in its ATP-driven conformational cycle.

Biophysical Journal · Apr 18, 2026Peer-reviewedBiochemistry

Coupling the role of lipids to the conformational dynamics of the ABC transporter P-gp

Dario De Vecchis, Lars V. Schäfer

This study uses molecular dynamics simulations to show how lipid environment and ATP affect the conformational dynamics and substrate cavity accessibility of P-gp conformers.

Biophysical Journal · Jun 21, 2024Peer-reviewedBiophysics

Structural basis for triacylglyceride extraction frommycobacterial inner membrane by MFS transporter Rv1410

Sille Remm, Dario De Vecchis, Jendrik Schöppe, Cedric A J Hutter, Imre Gonda, Michael Hohl, Simon Newstead, Lars V Schäfer, Markus A. Seeger

The paper reports the structure of MFS transporter Rv1410 and proposes a mechanism for triacylglyceride extraction from the mycobacterial inner membrane into the periplasm.

Nature Communications · Oct 13, 2023Peer-reviewedMolecular Biology