Markus A. Seeger

The paper identifies a nucleolar module involving Fap7 that ensures proper uS11 modification and incorporation into pre-ribosomes, safeguarding ribosome biogenesis.

This study uses synthetic nanobodies to identify functional regions of the Bacillus subtilis SMC complex, revealing the mid-region of the coiled coil as critical for DNA folding.

This study captures transient states of the ABC transporter TM287/288 using time-resolved small-angle X-ray scattering and reveals a transient occluded state in its ATP-driven conformational cycle.

The paper determines the cryo-EM structure of the hexameric MmpS4-MmpL4 complex from Mycobacterium tuberculosis, revealing the coiled-coil domain and conformational changes compared to the monomer.

The paper reports the structure of MFS transporter Rv1410 and proposes a mechanism for triacylglyceride extraction from the mycobacterial inner membrane into the periplasm.

The paper determines the structure of GlyT1 bound to an inhibitor, revealing its mechanism of non-competitive inhibition and informing drug design.

This paper introduces NestLink, a technology for simultaneous characterization of thousands of binder molecules, identifying rare binders and overcoming limitations of traditional screening methods.