Streptavidin-drug conjugates streamline optimization of antibody-based conditioning for hematopoietic stem cell transplantation
Aditya R. Yelamali, Ezhilarasi Chendamarai, Julie Ritchey, Michael P. Rettig, John F. DiPersio, Stephen P. Persaud
This paper develops a streptavidin-drug conjugate platform to efficiently optimize antibody-based conditioning for HSCT, finding that PBD dimer SGD-1882 is most effective for targeting HSCs and AML cells.
Blood Immunology & Cellular Therapy · Oct 7, 2025Peer-reviewedImmunology