Author

Mark J. Calcott

Victoria University of WellingtonORCID 0000-0002-7736-8095Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:metagenomics· 1

Frequent Co-Authors

David F. AckerleyiD· 2 shared Jeremy G. OweniD· 2 shared Edward M. R. McGuinnietyiD· 1 shared Gregory L. ChallisiD· 1 shared Luke J. StevensoniD· 1 shared Sarah R. MessengeriD· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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2 shared papersSynthetic Biology

David F. AckerleyORCID

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2 papers

Recent·Most cited

Metagenomic domain substitution for the high-throughput modification of non-ribosomal peptide analogues

Sarah R. Messenger, Edward M. R. McGuinniety, Luke J. Stevenson, Jeremy G. Owen, Gregory L. Challis, David F. Ackerley, Mark J. Calcott

The paper uses metagenomic domain substitution to generate novel non-ribosomal peptides by screening over 1,000 domains in a pyoverdine NRPS, resulting in 16 distinct products.

bioRxiv · May 31, 2023 · PreprintSynthetic Biology

Efficient rational modification of non-ribosomal peptides by adenylation domain substitution

Mark J. Calcott, Jeremy G. Owen, David F. Ackerley

The paper demonstrates that substituting adenylation domains in NRPS enzymes can generate novel non-ribosomal peptides, challenging previous assumptions about substrate specificity.

Nature Communications · Sep 11, 2020Peer-reviewedMolecular Biology