David F. Ackerley

Optimized chemogenetic ablation and regeneration of enteric nervous system neurons in zebrafish

This study develops a chemogenetic ablation model in zebrafish to study ENS neuron regeneration, showing complete restoration of most neuron subtypes but partial recovery of serotonergic neurons.

Molecular regulation of retinal regeneration is context specific

The paper identifies 18 genes regulating retinal ganglion cell regeneration in zebrafish using a combination of genetic models and single-cell omics.

Metagenomic domain substitution for the high-throughput modification of non-ribosomal peptide analogues

The paper uses metagenomic domain substitution to generate novel non-ribosomal peptides by screening over 1,000 domains in a pyoverdine NRPS, resulting in 16 distinct products.

Large-scale Phenotypic Drug Screen Identifies Neuroprotectants in Zebrafish and Mouse Models of Retinitis Pigmentosa

The paper identifies neuroprotective compounds for retinitis pigmentosa using cross-species drug screens in zebrafish and mouse models, finding additive effects in some combinations.

Efficient rational modification of non-ribosomal peptides by adenylation domain substitution

The paper demonstrates that substituting adenylation domains in NRPS enzymes can generate novel non-ribosomal peptides, challenging previous assumptions about substrate specificity.