Author

Laurent Yvan‐Charvet

InsermORCID 0000-0002-7748-4942Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

Anita M DeswaliD· 2 shared Efstratios KoutroumpakisiD· 2 shared Gilbert F. MejiaiD· 2 shared Guangyu WangiD· 2 shared Jared K. BurksiD· 2 shared Joerg HerrmanniD· 2 shared Jonghae LeeiD· 2 shared Jun‐ichi AbeiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Anita M DeswalORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintMay 30, 2026

Colchicine Directly Targets Aldehyde Dehydrogenase 2 (ALDH2) to Suppress Radiation-Induced Senescence and Atherosclerosis

Jun‐ichi Abe, Venkata Subrahman K Samanthapudi, Weiqing Chen…·Sivareddy Kotla

This study identifies ALDH2 as a direct target of colchicine, showing it suppresses radiation-induced senescence and atherosclerosis by modulating mitochondrial redox and macrophage function.

DOI 10.64898/2026.05.25.726409

humanproteomics

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Molecular BiologybioRxivPreprintJun 19, 2025

Downregulation of LATS1/2 Drives Endothelial Senescence-Associated Stemness (SAS) and Atherothrombotic Lesion Formation

Sivareddy Kotla, Jonghae Lee, Kyung Ae Ko…·Jun‐ichi Abe

This study shows that loss of LATS1/2 in endothelial cells promotes a senescence-associated stemness (SAS) state, leading to atherothrombotic plaque formation through metabolic and mitochondrial dysregulation.

1 citation

mousehuman

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