Jared K. Burks

Colchicine Directly Targets Aldehyde Dehydrogenase 2 (ALDH2) to Suppress Radiation-Induced Senescence and Atherosclerosis

This study identifies ALDH2 as a direct target of colchicine, showing it suppresses radiation-induced senescence and atherosclerosis by modulating mitochondrial redox and macrophage function.

Niche-level immune evasion in TP53 mutant AML residual disease revealed by spatial proteomics

This study uses spatial proteomics to reveal that TP53 mutant AML residual disease forms immunosuppressive niches in the bone marrow, segregated from T-cells, suggesting niche-level immune evasion.

The abscopal effect of Combination IRE with anti-PD-1 achieves local ablation and systemic control of PDAC

This paper shows that combining IRE with anti-PD-1 induces abscopal effects in PDAC by triggering immune activation and systemic antitumor responses.

Integration of spatial single-cell proteomics and spatial metabolomics reveals tumor microenvironment predictive of immunotherapy response in mucosal melanoma

Macrophage-Dendritic Cell-T-Cell Tetrads Orchestrate Antitumor Immunity and Response to Checkpoint Blockade

The paper identifies tetrads as a multicellular immune unit that correlates with antitumor immunity and response to checkpoint blockade in mouse and human tumors.

Downregulation of LATS1/2 Drives Endothelial Senescence-Associated Stemness (SAS) and Atherothrombotic Lesion Formation

This study shows that loss of LATS1/2 in endothelial cells promotes a senescence-associated stemness (SAS) state, leading to atherothrombotic plaque formation through metabolic and mitochondrial dysregulation.

Multimodal Spatial Proteomic Profiling in Acute Myeloid Leukemia

This study uses high-plex spatial proteomics to identify tertiary lymphoid-like structures in AML bone marrow and links them to patient outcomes.

Integrated single cell spatial multi-omics landscape of WHO grades 2-4 diffuse gliomas identifies locoregional metabolomic regulators of glioma growth

The paper integrates spatial multi-omics data from diffuse gliomas to identify locoregional metabolomic regulators linked to glioma growth and treatment resistance.

High Dimensional Proteomic Multiplex Imaging of the Central Nervous System Using the COMET(TM) System

The paper develops and validates a CNS-specific library and analysis platform using the COMET(TM) system for high-dimensional proteomic multiplex imaging of the central nervous system.