Amyotrophic lateral sclerosis associated mislocalisation of TDP-43 to the cytoplasm causes cortical hyperexcitability and reduced excitatory neurotransmission in the motor cortex.
Marcus S. Dyer, Laura A. Reale, Katherine E. A. Lewis, Adam K. Walker, Tracey C. Dickson, Adele Woodhouse, Catherine A. Blizzard
This study shows that TDP-43 mislocalization to the cytoplasm in motor cortex neurons causes hyperexcitability and reduced excitatory neurotransmission, linking early ALS pathology to TDP-43 mislocalization.
Journal of Neurochemistry · Oct 16, 2020Peer-reviewedNeuroscience