NeuroscienceJournal of NeurochemistryPeer-reviewed
Amyotrophic lateral sclerosis associated mislocalisation of TDP-43 to the cytoplasm causes cortical hyperexcitability and reduced excitatory neurotransmission in the motor cortex.
Marcus S. Dyer, Laura A. Reale, Katherine E. A. Lewis…·Catherine A. Blizzard
This study shows that TDP-43 mislocalization to the cytoplasm in motor cortex neurons causes hyperexcitability and reduced excitatory neurotransmission, linking early ALS pathology to TDP-43 mislocalization.
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