Author

Joanne C. McGrail

University of ManchesterORCID 0000-0002-7771-8526Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Stephen S. TayloriD· 3 shared Anthony TigheiD· 2 shared Bethany M. BarnesiD· 2 shared James AltringhamiD· 2 shared Samantha LittleriD· 2 shared Alicia EvansiD· 1 shared Camilla Coulson‐GilmeriD· 1 shared I‐Hsuan LiniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

Stephen S. TaylorORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Transcriptome-Driven Constraint-Based Modelling Reveals Metabolic Targets for Ovarian Cancer

Kate E. Meeson, Joanne C. McGrail, Jean‐Marc Schwartz, Stephen S. Taylor

This study uses transcriptome-driven constraint-based modeling to identify metabolic targets in ovarian cancer, revealing TPI1 as a potential therapeutic target supported by experimental validation.

Cancer & Metabolism · Mar 19, 2026Peer-reviewedCancer Biology

Transcriptional Circuitry in HGSOC: A Dynamic Three-State Model Informed by a Living Biobank of Purified Tumour Fractions

Bethany M. Barnes, Samantha Littler, Anthony Tighe, Alicia Evans, James Altringham, Louisa Nelson, I‐Hsuan Lin, Robert David Morgan, Joanne C. McGrail, Stephen S. Taylor

This study defines transcriptional subtypes in HGSOC using single-cell RNA sequencing and shows some tumours exhibit transcriptional plasticity.

bioRxiv · Jul 18, 2025 · PreprintCancer Biology

Exploring CDK4/6-Dependencies in ex vivo Ovarian Cancer Models

Jake Mcdonald-Pike, Camilla Coulson‐Gilmer, Samantha Littler, Bethany M. Barnes, James Altringham, Anthony Tighe, Joanne C. McGrail, Stephen S. Taylor

This study evaluates CDK4/6 dependency in ovarian cancer models, finding sensitivity in some subtypes and resistance in others, with CDKN2A as a potential biomarker.

bioRxiv · Jul 11, 2025 · PreprintCancer Biology