Author

Anthony Tighe

University of ManchesterORCID 0000-0001-7173-232XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

Stephen S. TayloriD· 3 shared Bethany M. BarnesiD· 2 shared James AltringhamiD· 2 shared Joanne C. McGrailiD· 2 shared Samantha LittleriD· 2 shared Alicia EvansiD· 1 shared Allen C. GaoiD· 1 shared Beat C. BornhauseriD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCancer Biology

Stephen S. TaylorORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A clinical-stage oncology compound selectively targets drug-resistant cancers

Kaitlin Long, Debanjan Bhattacharjee, Samuel H. Newman-Stonebraker, Simon Suhr, Brandon Q. Mercado, Emily Scheib, Anthony Tighe, Luciano Romero, Sarah L. Thompson, Erin L. Sausville, Kristen M. John, Linda Julian, Sanat Mishra, Olaf Klingbeil, Punya Gupta, , Jason M. Sheltzer

This study reveals that PAC-1, a clinical-stage oncology compound, targets drug-resistant cancers by disrupting iron homeostasis and exploiting MDR1 expression to induce iron depletion.

bioRxiv · Nov 26, 2025 · PreprintCancer Biology

Transcriptional Circuitry in HGSOC: A Dynamic Three-State Model Informed by a Living Biobank of Purified Tumour Fractions

Bethany M. Barnes, Samantha Littler, Anthony Tighe, Alicia Evans, James Altringham, Louisa Nelson, I‐Hsuan Lin, Robert David Morgan, Joanne C. McGrail, Stephen S. Taylor

This study defines transcriptional subtypes in HGSOC using single-cell RNA sequencing and shows some tumours exhibit transcriptional plasticity.

bioRxiv · Jul 18, 2025 · PreprintCancer Biology

Exploring CDK4/6-Dependencies in ex vivo Ovarian Cancer Models

Jake Mcdonald-Pike, Camilla Coulson‐Gilmer, Samantha Littler, Bethany M. Barnes, James Altringham, Anthony Tighe, Joanne C. McGrail, Stephen S. Taylor

This study evaluates CDK4/6 dependency in ovarian cancer models, finding sensitivity in some subtypes and resistance in others, with CDKN2A as a potential biomarker.

bioRxiv · Jul 11, 2025 · PreprintCancer Biology