Author

James Altringham

University of ManchesterORCID 0000-0002-8510-5172Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Anthony TigheiD· 2 shared Bethany M. BarnesiD· 2 shared Joanne C. McGrailiD· 2 shared Samantha LittleriD· 2 shared Stephen S. TayloriD· 2 shared Alicia EvansiD· 1 shared Camilla Coulson‐GilmeriD· 1 shared I‐Hsuan LiniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Anthony TigheORCID

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2 papers

Recent·Most cited

Transcriptional Circuitry in HGSOC: A Dynamic Three-State Model Informed by a Living Biobank of Purified Tumour Fractions

Bethany M. Barnes, Samantha Littler, Anthony Tighe, Alicia Evans, James Altringham, Louisa Nelson, I‐Hsuan Lin, Robert David Morgan, Joanne C. McGrail, Stephen S. Taylor

This study defines transcriptional subtypes in HGSOC using single-cell RNA sequencing and shows some tumours exhibit transcriptional plasticity.

bioRxiv · Jul 18, 2025 · PreprintCancer Biology

Exploring CDK4/6-Dependencies in ex vivo Ovarian Cancer Models

Jake Mcdonald-Pike, Camilla Coulson‐Gilmer, Samantha Littler, Bethany M. Barnes, James Altringham, Anthony Tighe, Joanne C. McGrail, Stephen S. Taylor

This study evaluates CDK4/6 dependency in ovarian cancer models, finding sensitivity in some subtypes and resistance in others, with CDKN2A as a potential biomarker.

bioRxiv · Jul 11, 2025 · PreprintCancer Biology