Near-atomic structure of the PorKN rings, disulfide bonded to PorG and bound to Attachment Complexes, provide mechanistic insights into the type IX secretion system
Dhana G. Gorasia, Eric G. Hanssen, Manasi Mudaliyar, Craig J. Morton, Sepideh Valimehr, Christine A. Seers, Lianyi Zhang, Matthew Thomas Doyle, Debnath Ghosal, Paul D. Veith, Eric Charles Reynolds
The paper presents a cryo-EM structure of the PorKN rings and shows their interaction with PorG and Attachment Complexes, proposing a mechanism for protein secretion in the Type IX Secretion System.
Nature Communications · Aug 19, 2025Peer-reviewedMicrobiology