Eric G. Hanssen

Whole cryo-FIB lamella acquisition at high magnification with rectangular beam montage cryo-electron tomography

This paper introduces a method for high-resolution cryo-electron tomography of large biological samples using rectangular beam montage, improving dose efficiency for yeast and human neuron specimens.

Electron tomography reveals mitochondrial network and cristae remodelling during cell differentiation in the human placenta

The paper uses electron tomography to study mitochondrial structure changes during placental cell differentiation, identifying morphological and functional shifts in mitochondria.

The trimeric structures of the extracellular domains of FAM171A1 and FAM171A2 neuronal proteins belong to a novel structural superfamily

This study determines the trimeric structures of FAM171A1 and FAM171A2 extracellular domains, revealing a novel structural superfamily and their oligomerization properties.

Near-atomic structure of the PorKN rings, disulfide bonded to PorG and bound to Attachment Complexes, provide mechanistic insights into the type IX secretion system

The paper presents a cryo-EM structure of the PorKN rings and shows their interaction with PorG and Attachment Complexes, proposing a mechanism for protein secretion in the Type IX Secretion System.

CardioVinci: building blocks for virtual cardiac cells using deep learning

CardioVinci uses deep learning to automate the analysis of 3D cardiac ultrastructure changes from large EM imaging datasets.

Identification of two independent COL5A1 variants in dogs with Ehlers Danlos syndrome

The paper identifies two COL5A1 mutations in dogs with EDS-like symptoms, confirming a genetic basis for the condition and demonstrating the utility of DNA sequencing in diagnosis.

Display of malaria transmission-blocking antigens on chimeric duck hepatitis B virus-derived virus-like particles produced in Hansenula polymorpha

This study develops a platform to display malaria transmission-blocking antigens on virus-like particles using yeast expression systems and demonstrates efficient production and purification of chimeric VLPs containing Pfs25 and Pfs230 variants.

Insights on the impact of mitochondrial organisation on bioenergetics in high-resolution computational models of cardiac cell architecture

The paper uses computational models to show that mitochondrial arrangement affects metabolite distribution and force dynamics in cardiac cells, with implications under hypoxia.