Hypoxic-Core (HyCo) Spheroids Recapitulate Hallmarks of Clinical Hypoxia: A Simple Chip-Based Method for Translational Oncology
Elena Refet-Mollof, Rodin Chermat, Julie Lafontaine, Run Zhou Ye, Thomas Gervais, Philip Wong
This paper introduces a microfluidic device to generate hypoxic-core spheroids that mimic clinical hypoxia in cancer, showing increased resistance to therapy and invasiveness.
bioRxiv · Apr 3, 2025 · PreprintCancer Biology