This study uses multimodal normative modeling on ATN biomarkers to analyze Alzheimer Disease heterogeneity, finding greater intra-group variation in more severe stages and a correlation between disease severity index and cognitive decline.

Alzheimer s & Dementia · Apr 1, 2025Peer-reviewedNeuroscience

Evaluating the association of APOE genotype and cognitive resilience in SuperAgers

Alaina Durant, Shubhabrata Mukherjee, Michael L. Lee, Seo‐Eun Choi, Phoebe Scollard, Brandon Skylar Klinedinst, Emily H. Trittschuh, Jesse B Mez, Lindsay A. Farrer, Katherine A. Gifford, Carlos Cruchaga, Jason J. Hassenstab, Adam Christian Naj, Li‐San Wang, Sterling C. Johnson, , Leslie S. Gaynor

This study examines the association between APOE genotype and cognitive resilience in SuperAgers, finding lower APOE-ε4 and higher APOE-ε2 frequencies in non-Hispanic White SuperAgers compared to controls and Alzheimer's cases.

medRxiv · Jan 7, 2025 · PreprintGenetic & Genomic Medicine

Functional variations in gamma-secretase activity are critical determinants of the clinical, biomarker, and cognitive progression of autosomal dominant Alzheimer's disease

Stephanie A. Schultz, Lei Liu, Aaron P. Schultz, Colleen D. Fitzpatrick, Raina Levin, Jean‐Pierre Bellier, Zahra Shirzadi, Nelly Joseph‐Mathurin, Charles D. Chen, Tammie L.S. Benzinger, Gregory Scott Day, Martin Rhys Farlow, Brian Andrew Gordon, Jason J. Hassenstab, Clifford R. Jack, , Dominantly Inherited Alzheimer Network Investigators

The paper quantifies Aβ production from PSEN1 variants and links it to clinical and biomarker progression in ADAD, showing strong associations with disease trajectories.

bioRxiv · Jul 4, 2023 · PreprintNeuroscience

Multimodal brain age estimates relate to Alzheimer disease biomarkers and cognition in early stages: a cross-sectional observational study

Peter R Millar, Brian Andrew Gordon, Patrick H. Luckett, Tammie L.S. Benzinger, Carlos Cruchaga, Anne M. Fagan, Jason J. Hassenstab, Richard J. Perrin, Suzanne E. Schindler, Ricardo Allegri, Gregory Scott Day, Martin Rhys Farlow, Hiroshi Mori, Georg Nübling, The Dominantly Inherited Alzheimer Network, , Beau M. Ances

This study examines how brain age estimates from different MRI modalities relate to Alzheimer's disease biomarkers and cognition in early stages.

eLife · Jan 6, 2023Peer-reviewedNeuroscience

Neuroimaging within the Dominantly Inherited Alzheimer's Network (DIAN): PET and MRI

Nicole Sarah McKay, Brian Andrew Gordon, Russ C. Hornbeck, Clifford R. Jack, Robert A. Koeppe, Shaney E. Flores, Sarah Keefe, Diana A. Hobbs, Nelly Joseph‐Mathurin, Qing Wang, Farzaneh Rahmani, Charles D. Chen, Austin A. McCullough, Deborah Koudelis, Jasmin Chua, , Dominantly Inherited Alzheimer Network

The paper describes MRI and PET protocols used in the DIAN study to investigate preclinical Alzheimer's disease and reports key imaging findings.

bioRxiv · Mar 25, 2022 · PreprintNeuroscience