Author

Jean‐Pierre Bellier

Brigham and Women's HospitalORCID 0000-0002-8758-8075Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:protein structure· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

Dennis J. SelkoeiD· 3 shared Jasmeer P. ChhatwaliD· 3 shared Lei LiuiD· 3 shared Adriana Saba· 2 shared Hyun‐Sik YangiD· 2 shared Aaron P. SchultziD· 1 shared Alan Y. Chen· 1 shared Amy Li· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersNeuroscience

Dennis J. SelkoeORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

CNS-Tau Specific Antibodies Illuminate Disease Signatures Across Tauopathies

Lei Liu, Yin Zheng, Luke Slominski, Qimin Quan, Adriana Saba, Jean‐Pierre Bellier, Han-Bin Yoo, Andrea Roman, Elizabeth L. Hennessey, Samadhi P. Wijethunga, Elif Lara Okyay, Michael B. Miller, Hyun‐Sik Yang, Dennis J. Selkoe, Jasmeer P. Chhatwal

The paper develops and validates CNS-tau-specific monoclonal antibodies for use in neuropathology and plasma biomarker assays across Alzheimer's disease and primary tauopathies.

bioRxiv · Sep 14, 2025 · PreprintNeuroscience

Identification of Fibrinogen as a Plasma Protein Binding Partner for Lecanemab Biosimilar IgG: Implications for Alzheimer's Disease Therapy

Jean‐Pierre Bellier, Andrea M. Román Viera, Caitlyn Christiano, Juliana A. U. Anzai, Stephanie Moreno, Emily C. Campbell, Lucas Godwin, Amy Li, Alan Y. Chen, Sarah Alam, Adriana Saba, Han bin Yoo, Hyun‐Sik Yang, Jasmeer P. Chhatwal, Dennis J. Selkoe, Lei Liu

This study identifies fibrinogen as a plasma protein binding partner for lecanemab biosimilar, suggesting it may affect drug half-life and free antibody levels in Alzheimer's disease therapy.

bioRxiv · May 1, 2024 · PreprintNeuroscience

Functional variations in gamma-secretase activity are critical determinants of the clinical, biomarker, and cognitive progression of autosomal dominant Alzheimer's disease

Stephanie A. Schultz, Lei Liu, Aaron P. Schultz, Colleen D. Fitzpatrick, Raina Levin, Jean‐Pierre Bellier, Zahra Shirzadi, Nelly Joseph‐Mathurin, Charles D. Chen, Tammie L.S. Benzinger, Gregory Scott Day, Martin Rhys Farlow, Brian Andrew Gordon, Jason J. Hassenstab, Clifford R. Jack, , Dominantly Inherited Alzheimer Network Investigators

The paper quantifies Aβ production from PSEN1 variants and links it to clinical and biomarker progression in ADAD, showing strong associations with disease trajectories.

bioRxiv · Jul 4, 2023 · PreprintNeuroscience