Author
University of CalgaryORCID 0000-0002-7806-1298Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
3 papers
Recent·Most cited
Mashiat Zaman, Joshua David, Ayshin Mehrabi…·Timothy E. Shutt
The paper identifies how pathogenic MFN2 variants cause mtDNA release into endosomes and mitochondrial-derived vesicles, triggering inflammation and myopathy, and suggests a therapeutic strategy using integrated stress response activation.
Mashiat Zaman, Govinda Sharma, Walaa Almutawa…·Timothy E. Shutt
The paper identifies a novel MFN2 variant, Q367H, linked to mtDNA-mediated inflammation in a patient with distal myopathy, revealing a pathomechanism connecting MFN2 dysfunction to inflammatory signaling.
Tyler Soule, Carly Sabine Pontifex, Nicole L. Rosin…·Gerald Pfeffer
This paper presents a method for snRNAseq from frozen human skeletal muscle, enabling analysis of cell types despite tissue degradation and pathological changes.