Ge Zhang

AptaGPT uses a generative pre-trained transformer to design aptamers, generating high-affinity sequences faster than traditional methods.

This study identifies OGRU, a lncRNA that alleviates unloading-induced bone loss by regulating the miR-320-3p/Hoxa10 axis in osteoblasts.

This study shows MACF1 is essential for bone formation by enabling SMAD7 nuclear translocation in MSCs, leading to ossification retardation and bone loss in mice.