MACF1 Facilitates SMAD7 Nuclear Translocation to Drive Bone Formation in Mice
Fan Zhao, Xiaoli Ma, Wuxia Qiu, Pai Wang, Ru Zhang, Zhihao Chen, Peihong Su, Yan Zhang, Dijie Li, Jianhua Ma, Chaofei Yang, Lei Chen, Chong Yin, Ye Edward Tian, Lifang Hu, , Airong Qian
This study shows MACF1 is essential for bone formation by enabling SMAD7 nuclear translocation in MSCs, leading to ossification retardation and bone loss in mice.
bioRxiv · Aug 25, 2019 · PreprintDevelopmental Biology