Author

Zhenghong Bi

Chinese Academy of SciencesORCID 0000-0002-7811-8012Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Minhui Ren· 3 shared Zhiyong LiuiD· 3 shared Guangqin WangiD· 2 shared Lei SongiD· 2 shared Tong Zhu· 2 shared Yu ZhangiD· 2 shared Yunpeng GuiD· 2 shared Chao LiiD· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersDevelopmental Biology

Minhui Ren

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3 papers

Recent·Most cited

Revisiting the potency of Tbx2 expression in transforming outer hair cells into inner hair cells at multiple ages in vivo

Zhenghong Bi, Minhui Ren, Yu Zhang, Shunji He, Lei Song, Xiang Li, Zhiyong Liu

This study investigates the effects of Tbx2 overexpression on OHC transdifferentiation into IHC-like cells across different ages, finding partial but incomplete reprogramming.

bioRxiv · Sep 17, 2023 · PreprintDevelopmental Biology

Defective mechanosensory transduction of the new inner hair cells prevents hearing recover in the damaged cochlea

Xiang Li, Minhui Ren, Yunpeng Gu, Tong Zhu, Yu Zhang, Jie Li, Chao Li, Guangqin Wang, Lei Song, Zhenghong Bi, Zhiyong Liu

This study shows that newly regenerated inner hair cells in the cochlea lack functional mechanosensory transduction, preventing hearing recovery despite successful cell regeneration.

bioRxiv · Feb 18, 2023 · PreprintNeuroscience

Tbx2 is essential for cochlear inner hair cell development and regeneration

Zhenghong Bi, Xiang Li, Minhui Ren, Yunpeng Gu, Tong Zhu, Shuting Li, Guangqin Wang, Suhong Sun, Yuwei Sun, Zhiyong Liu

This study identifies Tbx2 as essential for inner hair cell development and shows that its co-expression with Atoh1 can reprogram supporting cells into functional inner hair cells.

National Science Review · Aug 9, 2022Peer-reviewedDevelopmental Biology