Guangqin Wang

Deciphering the genetic interactions between Pou4f3, Gfi1 and Rbm24 in maintaining cochlear hair cell survival

This study investigates the genetic interactions between Pou4f3, Gfi1, and Rbm24 in cochlear hair cell survival using mouse models and identifies regulatory elements and expression patterns.

Defective mechanosensory transduction of the new inner hair cells prevents hearing recover in the damaged cochlea

This study shows that newly regenerated inner hair cells in the cochlea lack functional mechanosensory transduction, preventing hearing recovery despite successful cell regeneration.

Tbx2 is essential for cochlear inner hair cell development and regeneration

This study identifies Tbx2 as essential for inner hair cell development and shows that its co-expression with Atoh1 can reprogram supporting cells into functional inner hair cells.

Dual expression of Atoh1 and Ikzf2 promotes transformation of adult cochlear supporting cells into outer hair cells

This study shows that expressing Atoh1 and Ikzf2 in adult cochlear supporting cells converts them into Prestin+ outer hair cell-like cells, advancing OHC regeneration.