Zhiyong Liu

Frameshift variants in TBX2 underlie autosomal-dominant hearing loss with incomplete penetrance of nystagmus

The paper identifies TBX2 frameshift variants as the cause of autosomal-dominant hearing loss with incomplete nystagmus penetrance, validated through linkage analysis, sequencing, and mouse models.

Rbm24 maintains survival of cochlear outer hair cells by repressing Insm1

This study identifies Rbm24's role in repressing Insm1 to maintain cochlear outer hair cell survival and differentiation.

TMEM63B functions as a mammalian thirst receptor

This study identifies TMEM63B as a mammalian thirst receptor in the subfornical organ, showing it mediates osmotic and dehydration-induced thirst through ion channel activity.

Revisiting the potency of Tbx2 expression in transforming outer hair cells into inner hair cells at multiple ages in vivo

This study investigates the effects of Tbx2 overexpression on OHC transdifferentiation into IHC-like cells across different ages, finding partial but incomplete reprogramming.

Deciphering the genetic interactions between Pou4f3, Gfi1 and Rbm24 in maintaining cochlear hair cell survival

This study investigates the genetic interactions between Pou4f3, Gfi1, and Rbm24 in cochlear hair cell survival using mouse models and identifies regulatory elements and expression patterns.

Defective mechanosensory transduction of the new inner hair cells prevents hearing recover in the damaged cochlea

This study shows that newly regenerated inner hair cells in the cochlea lack functional mechanosensory transduction, preventing hearing recovery despite successful cell regeneration.

Tbx2 is essential for cochlear inner hair cell development and regeneration

This study identifies Tbx2 as essential for inner hair cell development and shows that its co-expression with Atoh1 can reprogram supporting cells into functional inner hair cells.

Dual expression of Atoh1 and Ikzf2 promotes transformation of adult cochlear supporting cells into outer hair cells

This study shows that expressing Atoh1 and Ikzf2 in adult cochlear supporting cells converts them into Prestin+ outer hair cell-like cells, advancing OHC regeneration.

Piezo2 mediates ultrasonic hearing via cochlear outer hair cells in mice

This study shows that Piezo2 in outer hair cells is essential for ultrasonic hearing in mice, but not for low-frequency hearing.

Stem cell intrinsic, Seven-up-triggered temporal factor gradients diversify intermediate neural progenitors

The paper identifies temporal RNA-binding protein gradients in Drosophila neuroblasts that regulate intermediate neural progenitor fate.