NeurosciencebioRxivPreprint
ARHGEF17 Deficiency Induces Endothelial Dysfunction and Intracranial Aneurysm Formation via RhoA/ROCK2/MLC Signaling Pathway
Jian Li, Hao Zhang, Chao Peng…·Xinyu Yang
This study shows that ARHGEF17 deficiency causes endothelial dysfunction and intracranial aneurysms via the RhoA/ROCK2/MLC pathway, with ROCK inhibition reversing these effects.