ARHGEF17 Deficiency Induces Endothelial Dysfunction and Intracranial Aneurysm Formation via RhoA/ROCK2/MLC Signaling Pathway
Jian Li, Hao Zhang, Chao Peng, Bangyue Wang, Yan E. Zhao, Xinyu Yang
This study shows that ARHGEF17 deficiency causes endothelial dysfunction and intracranial aneurysms via the RhoA/ROCK2/MLC pathway, with ROCK inhibition reversing these effects.
bioRxiv · Oct 14, 2025 · PreprintNeuroscience