Dual GLP-1 and GIP receptor agonist Tirzapetide plays an off-target role in the modulation of the β-adrenoceptors and glucose metabolism in hyperglycemic or senescent cardiac cells
Dunya Aydos, Zeynep Büşra Aksoy, Mehmet Altay Ünal, Kamil Can Akçalı, Ceylan Verda Bitirim, Belma Turan
This study investigates how Tirzapetide modulates β-adrenoceptors and glucose metabolism in cardiac cells under hyperglycemic or senescent conditions, revealing off-target effects beyond its primary GLP-1 and GIP receptor agonism.
bioRxiv · Apr 9, 2025 · PreprintMolecular Biology