Molecular BiologybioRxivPreprint
Dual GLP-1 and GIP receptor agonist Tirzapetide plays an off-target role in the modulation of the β-adrenoceptors and glucose metabolism in hyperglycemic or senescent cardiac cells
Dunya Aydos, Zeynep Büşra Aksoy, Mehmet Altay Ünal…·Belma Turan
This study investigates how Tirzapetide modulates β-adrenoceptors and glucose metabolism in cardiac cells under hyperglycemic or senescent conditions, revealing off-target effects beyond its primary GLP-1 and GIP receptor agonism.
DOI 10.1101/2025.04.09.648025