Molecular BiologyPLoS ONEPeer-reviewed
CRISPR/Cas9-based Editing of a Sensitive Transcriptional Regulatory Element to Achieve Cell Type-Specific Knockdown of the NEMO Scaffold Protein
Milad Babaei, Yuekun Liu, Shelly M. Wuerzberger‐Davis…·Thomas D. Gilmore
This paper uses CRISPR/Cas9 to disrupt a promoter element in 293T cells, eliminating NEMO expression and canonical NF-κB signaling while preserving non-canonical signaling.
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