Author

Paul G. Mermelstein

University of MinnesotaORCID 0000-0002-7829-8076Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 6 Research Focus:cell type annotation· 2 Assay:electronic health records· 2 Organism:rat· 1

Frequent Co-Authors

Andrew D. ChappiD· 4 shared Mark John ThomasiD· 4 shared Chau-Mi H. Phan· 3 shared Chinonso A. NwakamaiD· 3 shared Pramit P. Jagtap· 3 shared Adrina KocharianiD· 1 shared Andréa R. Collins· 1 shared Anna E. IngebretsoniD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersNeuroscience

Andrew D. ChappORCID

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Cocaine sensitization and accumbens shell plasticity depend on biological sex and gonadal hormones in C57BL/6J mice

Andrew D. Chapp, Chinonso A. Nwakama, Chau-Mi H. Phan, Pramit P. Jagtap, Erin B. Lind, Andréa R. Collins, Yanaira Alonso‐Caraballo, Mark John Thomas, Paul G. Mermelstein

This study shows that biological sex and gonadal hormones influence cocaine-induced behavioral and neuronal plasticity in mice, with males and females showing distinct responses.

bioRxiv · Dec 15, 2025 · PreprintNeuroscience

Fundamental Sex Differences in Cocaine-Induced Plasticity of D1R- and D2R-MSNs in the Mouse Nucleus Accumbens Core

Andrew D. Chapp, Hannah M. McMullan, Chau-Mi H. Phan, Pramit P. Jagtap, Mark John Thomas, Paul G. Mermelstein

This study investigates sex and estrous cycle differences in cocaine-induced changes to D1R- and D2R-MSN excitability in the mouse nucleus accumbens core, finding significant sex-specific effects.

Biology of Sex Differences · Nov 26, 2025Peer-reviewedNeuroscience

Cholinergic interneurons in the nucleus accumbens are a site of cellular convergence for corticotropin release factor and estrogen regulation

Kendra L. Olson, Anna E. Ingebretson, Eleftheria Vogiatzoglou, Paul G. Mermelstein, Julia C. Lemos

The paper investigates how estrogen and corticotropin releasing factor regulate cholinergic interneurons in the nucleus accumbens, finding sex-specific mRNA expression patterns and interactions.

bioRxiv · Apr 13, 2024 · PreprintNeuroscience

Fundamental Sex Differences in Cocaine-Induced Plasticity of D1- and D2-MSNs in the Mouse Nucleus Accumbens Shell

Andrew D. Chapp, Chinonso A. Nwakama, Pramit P. Jagtap, Chau-Mi H. Phan, Mark John Thomas, Paul G. Mermelstein

This study shows sex differences in cocaine-induced plasticity in D1- and D2-MSNs of the mouse nucleus accumbens shell, with males showing reduced D1-MSN excitability and females showing increased D2-MSN excitability.

bioRxiv · Jun 28, 2023 · PreprintNeuroscience

Physiological acetic acid concentrations from ethanol metabolism stimulate accumbens shell neurons via NMDAR activation in a sex-dependent manner

Andrew D. Chapp, Chinonso A. Nwakama, Paul G. Mermelstein, Mark John Thomas

This study shows acetic acid, an ethanol metabolite, increases excitability of accumbens shell neurons via NMDAR activation, with stronger effects in females.

bioRxiv · May 5, 2023 · PreprintNeuroscience

Neuroligin-3 in Dopaminergic Circuits Promotes Behavioral and Neurobiological Adaptations to Chronic Morphine Exposure

Dieter D. Brandner, Cassandra L. Retzlaff, Adrina Kocharian, Bethany J. Stieve, Mohammed A. Mashal, Paul G. Mermelstein, Patrick E. Rothwell

This study shows that Neuroligin-3 in dopamine neurons affects behavioral and neurobiological responses to chronic morphine exposure in mice.

bioRxiv · Mar 14, 2022 · PreprintNeuroscience

Effects of gonadectomy and androgen on neuronal plasticity in motivation and reward related brain regions in the male rat

Patty T. Huijgens, Eelke Mirthe Simone Snoeren, Robert L. Meisel, Paul G. Mermelstein

This study examines how gonadectomy and androgen replacement affect spine plasticity in brain regions related to motivation and reward in male rats.

Journal of Neuroendocrinology · Nov 6, 2020Peer-reviewedNeuroscience