Patrick E. Rothwell

This study shows that NMDA receptor loss in the medial prefrontal cortex impairs value updating and reward history integration in mice, mimicking schizophrenia-like cognitive deficits.

This study compares striatal pathology in SCA1 and HD mice, finding shared and distinct molecular and functional deficits in Medium Spiny Neurons.

This study investigates VGF's role in nucleus accumbens synaptic and opioid-evoked plasticity, finding it modulates drug-evoked adaptations and behavior.

This study identifies the N-terminal catalytic domain of ACE as the primary site for endogenous opioid peptide degradation in brain tissue and shows that inhibiting this domain reduces opioid degradation.

The paper identifies ACE inhibitors that enhance endogenous opioid signaling by reducing enkephalin degradation, showing analgesic effects in vivo.

This study investigates how NMDAR ablation in adolescent mice affects synaptic structure and function in the medial prefrontal cortex, revealing early disruption followed by compensatory recovery.

This study shows that dopamine in the nucleus accumbens reflects decision confidence and future value during re-evaluation and change-of-mind in mice.

This study examines how 16p11.2 duplication affects reward learning in mice, finding male-biased impacts in early training but no genotype effect in a bandit task, while NMDAR antagonism impairs choice flexibility in all animals.

The paper identifies nucleus accumbens inhibitory interneurons as a key site where mu opioid receptor expression promotes social behavior, distinct from its role in exogenous opioid sensitivity.

This study investigates sex differences in morphine sensitivity in neuroligin-3 knockout mice, finding distinct effects in males and females.

This paper develops PSA inhibitors to prolong enkephalin stability and reduce pain, showing analgesic effects in vivo and confirming their mechanism through pharmacokinetics and modeling.

This study compares synaptic plasticity in the nucleus accumbens under continuous vs interrupted morphine exposure in mice, finding divergent effects on inhibitory synapses and D1-MSN output.

This study characterizes neuropeptide Y interneurons in the nucleus accumbens and shows they are sensitive to mu opioid receptor activation, with sex- and receptor-dependent effects on synaptic transmission.

This study shows that Neuroligin-3 in dopamine neurons affects behavioral and neurobiological responses to chronic morphine exposure in mice.

This study shows that ACE inhibition enhances endogenous opioid signaling and reduces fentanyl-induced conditioned place preference in mice.

This study shows that partial reduction of mu opioid receptor signaling in mice leads to social behavior deficits and changes in nucleus accumbens microcircuitry.

This study shows that interrupting continuous opioid exposure increases drug-evoked adaptations in the mesolimbic dopamine system, leading to greater behavioral and transcriptional changes.

This study shows that fast-spiking interneurons in the nucleus accumbens reduce impulsive actions in mice by inhibiting medium spiny neurons through GABA signaling.