Transcriptome-informed brain cartography of polygenic risk and association with brain structure in major psychiatric disorders
Alessio Giacomel, Timothy R. Powell, Rodrigo R. R. Duarte, Giovanna Nordio, Steven Williams, Federico Turkheimer, Mattia Veronese, Daniel Martins, Danai Dima
The paper integrates transcriptome-wide association studies with brain atlases to map polygenic risk onto structural brain changes in psychiatric disorders, finding significant correlations in some disorders but not others.
Molecular Psychiatry · Mar 6, 2026Peer-reviewedNeuroscience