Rodrigo R. R. Duarte

Schizophrenia risk gene ZNF804A controls ribosome localization and synaptogenesis in developing human neurons

This study investigates the role of ZNF804A in human neurodevelopment, finding it regulates excitatory synapse formation through increased local protein translation in developing cortical glutamatergic neurons.

Transcriptome-informed brain cartography of polygenic risk and association with brain structure in major psychiatric disorders

The paper integrates transcriptome-wide association studies with brain atlases to map polygenic risk onto structural brain changes in psychiatric disorders, finding significant correlations in some disorders but not others.

A single-cell transposable element atlas of human cell identity

This study develops a tool to analyze transposable element expression in single-cell RNA sequencing data and builds an atlas showing TEs delineate cell types in human PBMCs.

Estradiol regulates local synthesis of synaptic proteome via sex-specific mechanisms.

This study shows estradiol increases local synaptic protein synthesis in both sexes, but mTOR signaling is sex-specifically required for certain synaptic proteins.

Acute IL-6 exposure triggers canonical IL-6R signalling in hiPSC microglia, but not neural progenitor cells.

The paper shows that acute IL-6 exposure activates canonical IL-6R signaling in hiPSC-derived microglia but not neural progenitor cells, with implications for neurodevelopmental disorders.

Attenuated transcriptional response to pro-inflammatory cytokines in schizophrenia hiPSC-derived neural progenitor cells

The paper shows that schizophrenia hiPSC-derived NPCs have a reduced transcriptional response to IFN-gamma compared to controls, with implications for synaptic development and mitochondrial genes.

Nanoscopic Clustering of Neuroligin-3 and Neuroligin-4X Regulates Growth Cone Organization and Size

This study shows that NLGN3/4X clustering at growth cones promotes neuritogenesis and actin organization in immature human neurons, with ASD-associated variants lacking these effects.

Schizophrenia Risk Proteins ZNF804A and NT5C2 Interact at Synapses

This study shows ZNF804A and NT5C2 interact at synapses in cortical neurons, suggesting they function as a complex in schizophrenia risk.

The impact of telomere shortening on human hippocampal neurogenesis: Implications for cognitive function and psychiatric disorder risk

This study models telomere shortening in human hippocampal progenitor cells and links it to reduced neurogenesis, cognitive impairment, and psychiatric disorder risk.

Schizophrenia risk from locus-specific human endogenous retroviruses

The paper identifies 148 HERVs associated with schizophrenia risk using comprehensive annotation and RNA-sequencing data from brain samples.

Psychiatric risk gene NT5C2 regulates protein translation in human neural progenitor cells

This study identifies NT5C2 as a psychiatric risk gene, showing its role in protein translation and AMPK signaling in neural progenitor cells and Drosophila melanogaster.