Daniel Martins

Molecular, cellular and network mapping of brain structural deviations in patients with Post-COVID19 syndrome

This study identifies structural brain deviations in post-COVID-19 patients using normative modelling and network analysis, linking them to TMPRSS2 expression and neural circuit disruptions.

Multiparametric MRI and imaging transcriptomics reveal molecular and cellular correlates of neurodegeneration in experimental multiple system atrophy

The paper uses imaging transcriptomics in a mouse model of MSA to link MRI patterns with gene expression, identifying molecular correlates of neurodegeneration.

Brain dynamics of attentional, default-mode and limbic networks are disrupted at rest in Post-COVID-19 Syndrome

This paper identifies altered dynamic brain states in Post-COVID-19 Syndrome using resting-state fMRI, showing reduced attentional states and increased limbic-DMN states linked to cognitive impairment and inflammation.

Transcriptome-informed brain cartography of polygenic risk and association with brain structure in major psychiatric disorders

The paper integrates transcriptome-wide association studies with brain atlases to map polygenic risk onto structural brain changes in psychiatric disorders, finding significant correlations in some disorders but not others.

Multimodal imaging suggests potential immune-vascular contributions to altered regional brain perfusion and oxygen metabolism in Post-COVID-19 Syndrome

This study uses multimodal MRI to find altered brain perfusion and oxygen metabolism in PCS, linked to cognitive and emotional symptoms.

Transcriptional and neurochemical signatures of cerebral blood flow alterations in schizophrenia and the clinical high-risk state for psychosis

The paper identifies cellular and neurochemical signatures associated with cerebral blood flow alterations in schizophrenia and clinical high-risk states using combined neuroimaging and transcriptomic data.

Modulation of functional networks related to the serotonin neurotransmitter system by citalopram: evidence from a multimodal neuroimaging study

This study examines how citalopram affects serotonin-related brain networks using neuroimaging, finding dose-dependent changes in functional connectivity linked to 5-HTT and 5-HT1AR availability.

Normative Modelling of Molecular-based Functional Neurocircuits Captures Clinical Heterogeneity Transdiagnostically in Neuropsychiatric Patients

The paper uses REACT and normative modelling to analyze functional neurocircuits in neuropsychiatric patients, revealing transdiagnostic deviations in neurotransmitter systems and symptom overlaps.

Two human brain systems micro-structurally associated with obesity

The paper investigates the association between obesity and two brain systems using MRI data from UK Biobank participants, finding distinct structural and genetic relationships.

Molecular-enriched functional connectivity in the human brain using multiband multi-echo simultaneous ASL/BOLD fMRI

This paper extends the REACT method to ASL fMRI, showing it can detect molecular-enriched functional connectivity comparable to BOLD fMRI, with complementary information.

The Effects of Propofol Anaesthesia on Molecular-enriched Networks During Resting-state and Naturalistic Stimulation

This study uses REACT to examine how propofol affects neurotransmission-related functional connectivity during rest and naturalistic stimulation, revealing changes in GABAergic, noradrenergic, and cholinergic networks.

Oxytocin modulates neurocomputational mechanisms underlying prosocial reinforcement learning

This study shows that oxytocin modulates prediction error encoding in the midbrain-sgACC pathway during prosocial learning, without affecting self-oriented learning.

Less is more: a dose-response account of intranasal oxytocin pharmacodynamics in the human brain

This study shows that lower doses of intranasal oxytocin have maximal effects on amygdala physiology, with subregion-specific responses and no disruption of cerebrovascular reactivity.

A candidate neuroimaging biomarker for detection of neurotransmission-related functional alterations and prediction of pharmacological analgesic response in chronic pain

This paper identifies neurotransmission-related functional connectivity biomarkers in chronic pain patients and shows their predictive value for analgesic response to duloxetine.

Imaging transcriptomics: Convergent cellular, transcriptomic, and molecular neuroimaging signatures in the healthy adult human brain

The paper uses imaging transcriptomics to link neuroimaging markers with transcriptomic and cellular correlates in the human brain, showing robust results across different parcellation methods.

Transcriptional and cellular signatures of cortical morphometric similarity remodelling in chronic pain

This study identifies cortical morphometric similarity remodelling in chronic pain and links it to transcriptomic changes in glial and neuronal genes across multiple pain syndromes.

Cellular and molecular signatures of in vivo GABAergic neurotransmission in the human brain

The paper identifies co-expression patterns between GABA receptor subunits and interneuron markers, linking them to in vivo PET radiotracer binding in human brain data.

Mapping social reward and punishment processing in the human brain: A voxel-based meta-analysis of neuroimaging findings using the Social Incentive Delay task

This study maps brain regions involved in social reward and punishment processing using a voxel-based meta-analysis of fMRI data from the Social Incentive Delay task.

Are single peripheral measurements of baseline oxytocin in saliva and plasma reliable biomarkers of the physiology of the oxytocin system in humans?

This study assesses the reliability of single baseline salivary and plasma oxytocin measurements as biomarkers of the oxytocin system in humans, finding poor reliability and weak correlation between saliva and plasma oxytocin.

Investigating resting brain perfusion abnormalities and target-engagement by intranasal oxytocin in women with bulimia nervosa and binge-eating disorder and healthy controls

This study examines resting brain perfusion differences in women with bulimia nervosa/binge-eating disorder and healthy controls, and evaluates if intranasal oxytocin normalizes perfusion in affected brain circuits.

Unravelling the effects of methylphenidate on the dopaminergic and noradrenergic functional circuits

This study uses REACT to analyze how methylphenidate affects dopaminergic and noradrenergic circuits in the brain and links these effects to behavioral responses in a reinforcement-learning task.

Effects of route of administration on oxytocin-induced changes in regional cerebral blood flow in humans

This study compares intranasal and intravenous oxytocin administration effects on regional cerebral blood flow, showing systemic OT increases drive amygdala perfusion changes and validating intranasal targeting of specific brain regions.