Timothy R. Powell

This study investigates the role of ZNF804A in human neurodevelopment, finding it regulates excitatory synapse formation through increased local protein translation in developing cortical glutamatergic neurons.

The paper integrates transcriptome-wide association studies with brain atlases to map polygenic risk onto structural brain changes in psychiatric disorders, finding significant correlations in some disorders but not others.

This study develops a tool to analyze transposable element expression in single-cell RNA sequencing data and builds an atlas showing TEs delineate cell types in human PBMCs.

This study shows estradiol increases local synaptic protein synthesis in both sexes, but mTOR signaling is sex-specifically required for certain synaptic proteins.

The paper shows that schizophrenia hiPSC-derived NPCs have a reduced transcriptional response to IFN-gamma compared to controls, with implications for synaptic development and mitochondrial genes.

This study shows ZNF804A and NT5C2 interact at synapses in cortical neurons, suggesting they function as a complex in schizophrenia risk.

This study models telomere shortening in human hippocampal progenitor cells and links it to reduced neurogenesis, cognitive impairment, and psychiatric disorder risk.

The paper identifies 148 HERVs associated with schizophrenia risk using comprehensive annotation and RNA-sequencing data from brain samples.

This study identifies NT5C2 as a psychiatric risk gene, showing its role in protein translation and AMPK signaling in neural progenitor cells and Drosophila melanogaster.

The paper evaluates 42 inflammatory markers in MDD cases and controls, finding strong confounding effects and limited predictive power of individual markers for MDD diagnosis.