Author

Sean B. Carroll

Howard Hughes Medical InstituteORCID 0000-0002-7839-5458Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Evolutionary Biology· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:rat· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Noah L. DowelliD· 3 shared Elda Eliza SancheziD· 2 shared Elizabeth Cahill· 2 shared Fiona P. UkkeniD· 2 shared Birte HöckeriD· 1 shared Cara Francesca SmithiD· 1 shared Jory van ThieliD· 1 shared Luis Escalona· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersEvolutionary Biology

Noah L. DowellORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The novel viper FETUA-3 protein evolved a unique mode of inhibiting snake venom metalloproteinases

Noah L. Dowell, Susana Vázquez Torres, Fiona P. Ukken, Milorad Andjelkovic, Mamta Hajra, Elizabeth Cahill, Birte Höcker, Rafael Fernández-Leiro, Sean B. Carroll

This study investigates how the rattlesnake FETUA-3 protein evolved to inhibit venom metalloproteinases through structural and functional analyses.

bioRxiv · Sep 29, 2026 · PreprintEvolutionary Biology

The genomic origins and evolutionary path to a key innovation in the world's most venomous snakes

Jory van Thiel, Noah L. Dowell, Cara Francesca Smith, Elda Eliza Sanchez, Sean B. Carroll

This study traces the genomic origins of four procoagulant venom toxins in Australian snakes and identifies a fifth toxin, showing two distinct evolutionary paths for their development.

Proceedings of the National Academy of Sciences · Sep 4, 2026Peer-reviewedEvolutionary Biology

Natures Antivenom: Combinations of conserved rattlesnake serum metalloproteinase inhibitors block the lethal action of viper venoms

Sean B. Carroll, Fiona P. Ukken, Yetunde A. Ayinuola, Luis Escalona, Montamas Suntravat, Elda Eliza Sanchez

This study shows that combinations of rattlesnake metalloproteinase inhibitors can neutralize viper venom lethality more effectively than commercial antivenoms.

Proceedings of the National Academy of Sciences · Jul 29, 2026Peer-reviewedMolecular Biology

Loss of a major venom toxin gene in a Western Diamondback rattlesnake population

Noah L. Dowell, Elizabeth Cahill, Sean B. Carroll

The paper investigates the loss of a major venom toxin gene, MPO1, in Western Diamondback rattlesnakes, finding it correlates with geographic distribution and is caused by inactivating mutations.

PLoS ONE · Jul 3, 2025Peer-reviewedEvolutionary Biology