Andrew L. Eagle

The paper investigates the distinct behavioral and electrophysiological roles of oxytocin neurons in the anterior and posterior paraventricular nucleus using genetic and pharmacological manipulations in mice.

The paper shows that astrocyte calcium signals and the protein hevin mediate cocaine-induced reward and synaptic plasticity in the nucleus accumbens.

This study shows that cocaine exposure increases calreticulin in the ventral hippocampus via ΔFosB, reducing excitability in the vHPC-NAc circuit and promoting cocaine seeking and reward.

The paper describes the generation and validation of a floxed FosB mouse line to enable spatial and temporal control of FosB gene silencing.