Alfred Jay Robison

Longitudinal diffusion tensor imaging identifies coordinated white matter remodeling during cocaine self-administration in mice

Repetitive Neuronal Activation Regulates Cellular Maturation State via Nuclear Reprogramming

The paper shows that repetitive neuronal activation induces nuclear reprogramming, leading to cellular maturation state changes with behavioral effects similar to ECT.

Oxytocin neurons in the anterior and posterior paraventricular nucleus have distinct behavioral functions and electrophysiological profiles

The paper investigates the distinct behavioral and electrophysiological roles of oxytocin neurons in the anterior and posterior paraventricular nucleus using genetic and pharmacological manipulations in mice.

Discovery of Small Molecules and a Druggable Groove That Regulate DNA Binding and Release of the AP1 Transcription Factor DeltaFOSB

The paper identifies a druggable groove on DeltaFOSB that allows small molecules to modulate its DNA binding and release, with one compound reducing genomic occupancy by 60% in vivo.

Efficient in vivo pharmacological inhibition of deltaFOSB, an AP1 transcription factor, in brain

This paper demonstrates the creation of YL0441, a highly effective inhibitor of DeltaFOSB that reduces genomic DNA binding sites by ~94% in APP mice.

Astrocytes control cocaine-induced synaptic plasticity and reward through the matricellular protein hevin

The paper shows that astrocyte calcium signals and the protein hevin mediate cocaine-induced reward and synaptic plasticity in the nucleus accumbens.

Cocaine, via ΔFosB, remodels gene expression and excitability in ventral hippocampus

This study shows that cocaine exposure increases calreticulin in the ventral hippocampus via ΔFosB, reducing excitability in the vHPC-NAc circuit and promoting cocaine seeking and reward.

FosB/ΔFosB activation in mast cells regulates gene expression to modulate allergic inflammation in male mice

This study shows that FosB/ΔFosB in mast cells regulates gene expression to reduce allergic inflammation in male mice by enhancing DUSP4 expression.

Chronic social defeat stress induces a depression-relevant outcome in male prairie voles

This study shows that repeated social defeat stress in male prairie voles leads to depression-like behaviors including reduced sociability, anhedonia, and spatial memory impairment.

Impaired KDM2B-mediated PRC1 recruitment to chromatin causes neural stem cell senescence and ASD/ID-like behavioral deficits

This study shows that KDM2B dysfunction leads to neural stem cell senescence and ASD/ID-like behaviors in mice, linking 12q24.31 microdeletions to neurodevelopmental disorders.

Loss of ASH1L in developing brains causes autistic-like behaviors in a mouse model

This study shows that loss of ASH1L in developing mouse brains leads to autistic-like behaviors and cognitive impairments, establishing a causal link between ASH1L mutations and ASD/ID.

Generation and validation of a floxed FosB mouse line

The paper describes the generation and validation of a floxed FosB mouse line to enable spatial and temporal control of FosB gene silencing.