Author

Michael Tyler Guinn

Baylor College of MedicineORCID 0000-0002-7891-8765Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Organism:non-human primate· 1 Research Focus:perturbation response prediction· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Amir ArdeshiriD· 1 shared Anthony E. DavisiD· 1 shared Chancellor SmithiD· 1 shared Christy L. LavineiD· 1 shared Cody FelliD· 1 shared Danna MurungiiD· 1 shared Erin Haupt· 1 shared Gábor BalázsiiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperBioengineering

Amir ArdeshirORCID

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2 papers

Recent·Most cited

Once yearly cell-based therapy for sustained and dose tunable delivery of monoclonal antibodies

Cody Fell, Anthony E. Davis, Shalini Pandey, Michael Tyler Guinn, Zeshi Wang, Jonathon DeBonis, Chancellor Smith, Nathan Brown, Danna Murungi, 김연주, Imaan Mohandessi, Patrick Bednarz, Amir Ardeshir, Erin Haupt, Samuel Cuevas, , Omid Veiseh A

This paper develops a cell-based therapy that enables sustained, dose-tunable delivery of monoclonal antibodies through a single administration, demonstrating long-term efficacy and safety in preclinical models.

Science Advances · Oct 2, 2026Peer-reviewedBioengineering

Noise-Reducing Negative-Feedback Optogenetic Circuits in Mammalian Cells

Michael Tyler Guinn, Gábor Balázsi

The paper develops optogenetic circuits with negative feedback to reduce gene expression noise and control gene activity in mammalian cells.

bioRxiv · Apr 7, 2019 · PreprintSynthetic Biology