Fully Automated MRI-based Analysis of the Locus Coeruleus in Aging and Alzheimer's Disease Dementia using ELSI-Net
Max Dünnwald, Friedrich Krohn, Alessandro Sciarra, Mousumi Sarkar, Anja Schneider, Klaus Fließbach, Okka Kimmich, Frank Jessen, Ayda Rostamzadeh, Wenzel Glanz, Enise Irem Incesoy, Stefan Johannes Teipel, Ingo Kilimann, Doreen Göerß, Annika E. Spottke, , Matthew J. Betts
This paper introduces ELSI-Net, a deep learning method for automated Locus Coeruleus segmentation and feature extraction in aging and Alzheimer's Disease dementia, showing high agreement with manual ratings and correlations to CSF biomarkers.
Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · Apr 1, 2025Peer-reviewedBioinformatics