Emrah Düzel

Entorhinal grid coding as a functional link between tau accumulation and episodic memory in human aging

The paper investigates how tau accumulation in the entorhinal cortex affects episodic memory by analyzing grid-cell-like signals in older adults using MRI and tau PET.

Mesoscale medial temporal lobe connectivity patterns relate to tau pathology and memory in older adults

This study examines how mesoscale connectivity patterns in the medial temporal lobe relate to tau pathology and memory in older adults, finding distinct associations with age and AD pathology.

Automated quantification of white matter hyperintensity confluence: A measure of spatial organisation beyond volume and visual rating scales

This paper introduces an automated method to quantify white matter hyperintensity confluence, showing it correlates with cognitive performance and dementia subtypes beyond volume.

Disrupted Forward Connectivity in Parieto-temporal Network Impairs Memory Performance in Alzheimer's Disease

The paper examines how disrupted forward connectivity in the parieto-temporal network relates to memory impairment and AD pathology using fMRI and DCM in a longitudinal study.

Dynamic shifts between pattern separation and reinstatement in human CA3 and dentate gyrus

This study shows that pattern separation and reinstatement in the hippocampus dynamically shift based on stimulus similarity and hippocampal position during memory encoding.

Characterization and Validation of Compressed Sensing for Time-of-Flight MRI Angiography of the Human Brain at 3T and 7T

This study evaluates compressed sensing in TOF-MRA at 3T and 7T, finding significant differences in CNR and vessel diameter measurements across CS factors.

Dysfunction of the episodic memory network in the Alzheimer's disease cascade

This study examines how episodic memory network dysfunction relates to AD biomarkers, neurodegeneration, and cognition using longitudinal fMRI data from the DZNE study.

Pupil dilation as a marker of attention/effort in aging and mild cognitive impairment

Hippocampal-cortical connectivity relates to inter-individual differences and training gains in distinguishing similar memories

This study examines how hippocampal-cortical connectivity relates to individual differences and training gains in mnemonic discrimination.

Differences in LC integrity and fMRI activations in healthy aging and MCI associated with successful memory encoding

The paper examines how locus coeruleus integrity and fMRI activations relate to memory encoding in healthy aging and MCI.

Different dopaminergic circuits defined by D2/D3 receptor availablity patterns show structure-specific links to memory in ageing

This study links dopamine receptor availability in specific brain regions to memory performance in older adults, identifying distinct dopaminergic circuits associated with different memory outcomes.

APOE stratified genome-wide association studies provide novel insights into the genetic etiology of Alzheimers's disease

This study performs APOE-stratified GWAS to uncover genetic mechanisms underlying Alzheimer's disease risk and response to therapies.

Fully Automated MRI-based Analysis of the Locus Coeruleus in Aging and Alzheimer's Disease Dementia using ELSI-Net

This paper introduces ELSI-Net, a deep learning method for automated Locus Coeruleus segmentation and feature extraction in aging and Alzheimer's Disease dementia, showing high agreement with manual ratings and correlations to CSF biomarkers.

Decoding Salience: A Functional Magnetic Resonance Imaging Investigation of Reward and Contextual Unexpectedness in Memory Encoding and Retrieval

This study investigates how reward and contextual unexpectedness affect memory encoding and retrieval using fMRI, identifying distinct brain regions and pathways involved.

Unveiling the Power of High-Dimensional Cytometry Data with cyCONDOR

The paper introduces cyCONDOR, a computational framework for high-dimensional cytometry data analysis, offering scalable and user-friendly tools for preprocessing, clustering, and downstream biological interpretation.

Cognitive Reserve Against Alzheimer's Pathology Is Linked to Brain Activity During Memory Formation

The paper links cognitive reserve to brain activity during memory formation, showing it moderates the impact of Alzheimer's pathology on cognitive performance and predicts slower decline.

SMAS: Structural MRI-Based AD Score using Bayesian VAE

This paper introduces SMAS, a Bayesian VAE-based AD score from structural MRI data, showing strong correlations with cognitive decline and brain atrophy markers, and outperforming existing measures in predicting AD.

Evaluating phasic transcutaneous vagus nerve stimulation (taVNS) with pupil dilation: the importance of stimulation intensity and sensory perception

This study evaluates the effects of phasic taVNS on pupil dilation in younger adults, finding that higher intensity and perceived stimulation lead to greater dilation, with intensity having a stronger effect than frequency.

Increased recognition memory precision with decreased neural discrimination

This study shows that adaptive training improves memory precision by reducing neural activity differences between new and familiar experiences, despite increased activity in familiar experiences.

Fornix fractional anisotropy mediates the association between Mediterranean diet adherence and memory four years later in older adults without dementia

The paper examines if fractional anisotropy of the fornix mediates the link between Mediterranean diet adherence and verbal memory decline in older adults over four years.

Diagnostic images for mild cognitive impairment reveal biomarker status and abnormal scene processing

The paper identifies diagnostic images that correlate with Alzheimer's biomarkers and show differential neural processing in MCI patients compared to healthy controls.

It is the Locus Coeruleus! Or... is it? : A proposition for analyses and reporting standards for structural and functional magnetic resonance imaging of the noradrenergic Locus Coeruleus

This paper proposes spatial transformation and quality assessment methods for reliably imaging the small noradrenergic locus coeruleus using structural and functional MRI.

Plasma concentrations of anti-inflammatory cytokine TGF-β are associated with hippocampal structure related to explicit memory performance in older adults

The paper examines the association between plasma TGF-β1 levels and hippocampal structure in older adults, finding a positive correlation with memory performance.

Single-value scores of memory-related brain activity reflect dissociable neuropsychological and anatomical signatures of neurocognitive aging

The paper develops single-value fMRI scores to capture age-related differences in memory-related brain activity and links them to cognitive function in older adults.

Structural and functional MRI data differentially predict chronological age and behavioral memory performance

The paper uses SVM to predict age and memory performance from structural and functional MRI data, finding gray matter volume best predicts age while task-based fMRI contrasts best predict memory performance.

Functional connectivity and information pathways in the human entorhinal-hippocampal circuitry

The paper identifies two functional pathways in the human entorhinal-hippocampal circuitry that process scene and object information differently.

Lifelong musical activity is associated with multi-domain cognitive and brain benefits in older adults

This study finds that lifelong musical activity is linked to better cognitive abilities and preserved brain structure in older adults, suggesting it may enhance cognitive resilience.

Individualized Gaussian Process-based Prediction of Memory Performance and Biomarker Status in Ageing and Alzheimer's disease

The paper uses Gaussian process multikernel modeling to predict memory performance and CSF biomarkers in ageing and Alzheimer's disease using MRI and other data.

Perceived and mentally rotated contents are differentially represented in cortical depth of V1

The paper shows that perceived and mentally rotated visual contents are represented in different cortical depth regions of V1, suggesting functional segregation through anatomical compartmentalization.

A comprehensive score reflecting memory-related fMRI activations and deactivations as potential biomarker for neurocognitive aging

The paper introduces and validates a comprehensive fMRI score, FADE-SAME, to quantify memory-related neural activity changes associated with neurocognitive aging.